Quiz print-out 26 March 2012

GIVE REASONS

1. Post Kala-Azar Dermal Leishmanoid.

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2. Hypergammaglobunaemia in sleeping sickness.

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3. In giardiasis, stool examination should be repeated.

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4. Toxoplasmosis is considered an opportunistic disease.

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5. Plasmodium falciparum infection causes malignant malaria.

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CASE

A young woman works in a medical laboratory. She had been married for 2 years during which

she got pregnant twice and aborted twice. Laboratory investigations revealed a parasitic cause.

a) What is this parasite?

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b) How can you confirm the diagnosis?

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c) What is the mode of infection?

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d) What is the treatment?

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GIVE REASONS

1. May develop due to spontaneous arrest of the disease or due to incomplete treatment with antimony compounds.

2. Total IgM is always elevated due to antigenic variation of the surface coat of the organisms.

3. In giardiasis, the parasite is not regularly excreted in stool.

4. Toxoplasmosis is asymptomatic in the great majority of cases. if it infects an immunocompromized patient, the patient develops acute disseminated toxoplasmosis that may end fatally.

5. P. falciparum infection is usually severe, fatal and causes malignant malaria. In this infection, parasitized cells develop knobs on their surface. So they adhere together and to specific receptors on the endothelial cells of blood capillaries of internal organs. This leads to partial occlusion of capillaries that may cause anoxia and necrosis which may be fatal. According to the site of occlusion of blood vessels, the clinical picture of falciparum malaria takes different forms.


CASE

a) Toxoplasma gondii
b), c) and D) revise your text book