Quiz print-out 12 March 2012

1. Pathogenesis of vivax malaria is due to

A. Persistence of hypnozoites in the liver

B. Rupture of hepatocytes and release of schizonts content

C. Rupture of RBCs and liberation of pigment and parasite products

D. Formation of gametocytes in the blood stream


2. Malarial relapses are due to

A. Flaring up parasitemia

B. Cytoadherence in cerebral vessels.

C. Immune suppression

D. Activation of hypnozoites.


3. Nephrotic syndrome occurs in quartan malaria.

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4. Recrudescence of malarial attacks are due to reactivation of dormants of hypnozoites in the liver cells. ( T/F )


5. Black water fever is due to glomerulonephritis complicating infection with Plasmodium malariae. ( T/F )


6. A journalist was admitted to the hospital comatosed. A history of travelling to West Africa 2 weeks ago was given. The physician suspected a brain lesion of parasitic origin. Stool examination was negative. Blood film was positive for Plasmodium falciparum infection.

a) How did the patient develop the brain lesion?

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b) What early clinical symptoms you expect in the patient’s history?

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c) What other serious complications that may develop?

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d) How can you treat and prevent such condition?

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1.A


2.D


3.Due to immune complex deposition on the glomerular walls


4.False-dueto flaring up parasitemia


: 5.False-P.Falciparum


6a)Parasitized RBCs develop knobs on their surface. so, they adhere together and to specific receptor on endothelial cells of blood capillary of brain, lead to partial occlusion, anoxia and necrosis of the brain tissue.

b)Malarial attacks every 36-48 hours or irregular

c)Dysenteric malaria, pulm. edema, algidmalaria, black water fever, hypoglycemia and renal disease