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Tahun 3.kita separuh doktor.
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heme.27 march

+4
ayunishafaf
nisa mohd zaidan
ayien
Hamz!!
8 posters

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1heme.27 march Empty heme.27 march Mon Mar 28, 2011 12:48 am

Hamz!!

Hamz!!
Admin
Admin

Ok, as salam,
biarlah saya yang memulakannya,
baiklah,
hari ini ikhwah belajar tajuk heme,
synthesis and abnormalities.
akhwat pun sama juga ke?
xpasti.

heme.27 march Heme10
ignore the hideous drawing pls.


so anybody want to share anything?
or to ask if any musykillah.
inshaAllah, ada antara batch kita yg boleh jawabkan.
this is how this forum will work.

p/s-masih menunggu subjek master biochem untuk berdaftar. bounce bounce

http://wordsfromtheorient.blogspot.com/

2heme.27 march Empty Re: heme.27 march Mon Mar 28, 2011 5:08 am

Hamz!!

Hamz!!
Admin
Admin

haih, memang aku buat topik nih untuk aku discuss sorg2.
kan kan kan. Mad Mad Mad Mad

http://wordsfromtheorient.blogspot.com/

3heme.27 march Empty Re: heme.27 march Mon Mar 28, 2011 6:22 am

ayien

ayien
Lab Coater
Lab Coater

Hamz!! wrote:haih, memang aku buat topik nih untuk aku discuss sorg2.
kan kan kan. Mad Mad Mad Mad
kesian nye..huk3...
xpe2 ammar..
heme snynthsis start by 2..GLYCINE AND SUCCINYL COA.
banyak step kot...

4heme.27 march Empty Re: heme.27 march Mon Mar 28, 2011 6:27 am

Hamz!!

Hamz!!
Admin
Admin

wah terharunya aku ada reply.
hekhek

dan dia menggunakan enzyme ALA synthase.kankan?
menjadi a-amino B-ketoadipcocid something,
dan berlaku di mitochondria of Bone marrow and Liver.

btw aku xamik lg lah buku biochem vol2.
cmne nih???

http://wordsfromtheorient.blogspot.com/

5heme.27 march Empty Re: heme.27 march Mon Mar 28, 2011 6:33 am

ayien

ayien
Lab Coater
Lab Coater

ya..enzyme ALA synthtse(combine wit PLP) form gamma aminolevulate...

yang pnting PBG...2 ALA combine form PBG by dehydration...enzyme nye ALA dehydratase...

6heme.27 march Empty Re: heme.27 march Mon Mar 28, 2011 6:44 am

Hamz!!

Hamz!!
Admin
Admin

oh so

Succinyl-CoA + Glycine >>>>>>>> gamma(ke delta?)-aminolevulate
(ALA-synthase)

then

2ALA>>>>>>>>>>>>>>PBG
(ALA dehydratase)

a-amino B-ketoadipcocid tu amende plak?

http://wordsfromtheorient.blogspot.com/

7heme.27 march Empty Re: heme.27 march Mon Mar 28, 2011 7:53 am

nisa mohd zaidan


Book Lovers
Book Lovers

Hamz!! wrote:oh so

Succinyl-CoA + Glycine >>>>>>>> gamma(ke delta?)-aminolevulate
(ALA-synthase)

then

2ALA>>>>>>>>>>>>>>PBG
(ALA dehydratase)

a-amino B-ketoadipcocid tu amende plak?

a-amino B-ketoadipcocid tu keto acid 6 carbon.ia menghasilkan ALA lepas buat decarboxylation.sory kalau salah sbb ngantuk2 gak kt kelas td.

8heme.27 march Empty Re: heme.27 march Mon Mar 28, 2011 8:06 am

Hamz!!

Hamz!!
Admin
Admin

owhh,
maknanya dia dtg dpd succ-Coa dgn glycine dulu? pastu baru decarboxylation ke ALA?
i c, ic

http://wordsfromtheorient.blogspot.com/

9heme.27 march Empty Re: heme.27 march Tue Mar 29, 2011 3:55 am

ayunishafaf

ayunishafaf
Star Member
Star Member

1)pe beza erythropoietic porphyria ngn hepatic porphyria?
2) ALA may inhibit ATPase in the nervous system, cmner this inhibition cause abdominal pains + neuropsychiatric symptoms

10heme.27 march Empty Re: heme.27 march Tue Mar 29, 2011 6:08 am

Hamz!!

Hamz!!
Admin
Admin

hepatic porphyria happens when accumulating biosynthetic intermediates form in the liver and the symptoms are caused by the action of these intermediates to the nervous system.

Autonomic dysfunction causes by action on the sympa, parasym.
Pain causes by stimulation of visceral pain fibres.

So maybe jawapan ni xclear sgt.atleast ada la sikit idea.
aku malas nak baca bnyak2.
kalau rajin buka ni.page 610-611.






klikkk kalau rajin!





tak tahu la kalau dah ada dlm buku.
aku xde buku lg

http://wordsfromtheorient.blogspot.com/

11heme.27 march Empty Re: heme.27 march Tue Mar 29, 2011 6:43 am

frenzyfish

frenzyfish
Book Lovers
Book Lovers

hohoh...time kaseh kpd admin yg tlg buker topik....subjek master biochem pihak akhawat dh melapor diri yerrrr...yg ikhwah x tau laaa dh daftar ke blom... Shocked Shocked

sy nk bg respons kat soalan syafaf tp x tau laaa btol ker tak....
1.beza erythropoietic ngan hepatic porphyria....heme synthesis ni berlaku nyer kat liver ngan bone marrow..so,kalo erythropoietic porphyria tu bg effect kat bone marrow seterusnya menyebabkan anemia...kalo hepatic type plop,effect akn t,jadi kat liver.kat liver ader bnyk enzymes utk bnyk proses mcm gluconeogenesis,detoxification dll...so,enzymes ni akn effected la kot,...dlm text book ade state "attacks are precipitated byintake of alcohol,estrogens,and liver toxins and other forms of liver diseases."makne nyer,kalo laaa liver tu ader disease,tambah plop dgn porphyria ni,lg laa bgander-gander side effect nyer..

2.ALA may inhibit ATPase in the nervous system...kalo yg sy ingat,ATPase ni diperlukan utk sodium potassium pump kan dlm nervous system ,m.aser kiter blajo thn 1 dulu...sbb nk balancekan amount of na/k.so,kalo ATPase inhibited,akn berlaku something wrong laa kat nervous system..toxic to abdominal nerves to MAYBE sbb ALA ni bnyk accumulate kat liver tmpt heme synthesis b,laku..so,abdominal nerves laa mangser terdekat utk diserang.. kat cns plop mungkin jd neuropsychiatric symptom tu...

tp,sori laaa kalo salah.....sy x search and x rujuk maner2x pown ni...maen bantai jerr...saper yg lebey arif and faham tu,tlg bg respons yerrrr...shafaf kalo ader pndpt laen,x setuju ker,respons yerrr...

12heme.27 march Empty Re: heme.27 march Tue Mar 29, 2011 6:56 am

ayunishafaf

ayunishafaf
Star Member
Star Member

frenzyfish wrote:hohoh...time kaseh kpd admin yg tlg buker topik....subjek master biochem pihak akhawat dh melapor diri yerrrr...yg ikhwah x tau laaa dh daftar ke blom... Shocked Shocked

sy nk bg respons kat soalan syafaf tp x tau laaa btol ker tak....
1.beza erythropoietic ngan hepatic porphyria....heme synthesis ni berlaku nyer kat liver ngan bone marrow..so,kalo erythropoietic porphyria tu bg effect kat bone marrow seterusnya menyebabkan anemia...kalo hepatic type plop,effect akn t,jadi kat liver.kat liver ader bnyk enzymes utk bnyk proses mcm gluconeogenesis,detoxification dll...so,enzymes ni akn effected la kot,...dlm text book ade state "attacks are precipitated byintake of alcohol,estrogens,and liver toxins and other forms of liver diseases."makne nyer,kalo laaa liver tu ader disease,tambah plop dgn porphyria ni,lg laa bgander-gander side effect nyer..

2.ALA may inhibit ATPase in the nervous system...kalo yg sy ingat,ATPase ni diperlukan utk sodium potassium pump kan dlm nervous system ,m.aser kiter blajo thn 1 dulu...sbb nk balancekan amount of na/k.so,kalo ATPase inhibited,akn berlaku something wrong laa kat nervous system..toxic to abdominal nerves to MAYBE sbb ALA ni bnyk accumulate kat liver tmpt heme synthesis b,laku..so,abdominal nerves laa mangser terdekat utk diserang.. kat cns plop mungkin jd neuropsychiatric symptom tu...

tp,sori laaa kalo salah.....sy x search and x rujuk maner2x pown ni...maen bantai jerr...saper yg lebey arif and faham tu,tlg bg respons yerrrr...shafaf kalo ader pndpt laen,x setuju ker,respons yerrr...

klu yg kt liver tuh, amnde maksud mas? ke maksudnyer cmni... enzymes bese synthesised kt liver, kan? ke kt mner? pastu klu ad liver disease, so x ley hsilkan enzymes 4 heme synthesis, pastu x ley la bt heme snythesis, pastu pathway tersekat, accumulation of porphyrinogen,ALA,PBG then occur, pastu jd porphyria? cm2 ker??

13heme.27 march Empty Re: heme.27 march Tue Mar 29, 2011 7:00 am

frenzyfish

frenzyfish
Book Lovers
Book Lovers

ha ah.......sy paham mcm tu laaaa....sebijik2x samer....tp ntah lerrr kalo syok sendiri...hehehe..tp logik jer kan aper yg kiter fikir tu..

14heme.27 march Empty Re: heme.27 march Tue Mar 29, 2011 7:06 am

ayunishafaf

ayunishafaf
Star Member
Star Member

frenzyfish wrote:ha ah.......sy paham mcm tu laaaa....sebijik2x samer....tp ntah lerrr kalo syok sendiri...hehehe..tp logik jer kan aper yg kiter fikir tu..

ooo, tu klu kt liver... so klu kt bone marrow lak, sal pe lak... npe smpai leh jd anemia?? kurg RBC's production ker? amnde kaitn anemia ngn porphyria??

15heme.27 march Empty Re: heme.27 march Tue Mar 29, 2011 7:11 am

frenzyfish

frenzyfish
Book Lovers
Book Lovers

ooowwhhh...kaitan anemia dgn porphyria...ni yg sy paham laa....ader jer org tanyer dlm kls dulu,pastu prof jawab,..tp maser tu sy kat alam laen dah,x dgr sgt jwpn prof......kalo ader porphyria,x bley wat heme,......heme penting nk wat hemoglobin,hemoglobin penting wat rbcs.....so,biler ader porphyria,kurang heme,kurang hemoglobin,kurang rbc's.....jadi laaa anemia...

16heme.27 march Empty Re: heme.27 march Tue Mar 29, 2011 7:24 am

ayunishafaf

ayunishafaf
Star Member
Star Member

ooo... cat

17heme.27 march Empty Re: heme.27 march Wed Mar 30, 2011 2:59 am

afnan fakhrurazi

afnan fakhrurazi
Pro Member
Pro Member

Hamz!! wrote:oh so



Succinyl-CoA + Glycine >>>>>>>> gamma(ke delta?)-aminolevulate
(ALA-synthase)

then

2ALA>>>>>>>>>>>>>>PBG
(ALA dehydratase)

a-amino B-ketoadipcocid tu amende plak?



delta @ alpha, dua2 btl, disebabkan rotation carbon tuh..
then a-amino B-ketoadipate tuh intermiediates yg dihasilkan untuk first reaction untuk menjadi ALA , dua2 action nih guna ALA synthase

18heme.27 march Empty Re: heme.27 march Thu Mar 31, 2011 1:35 am

Muhammadhusnaim


Lab Coater
Lab Coater

law gtu cmne aku nk wat new post??
xpaham la aku gune nde ni..

19heme.27 march Empty Re: heme.27 march Thu Mar 31, 2011 2:51 am

Hamz!!

Hamz!!
Admin
Admin

Muhammadhusnaim wrote:law gtu cmne aku nk wat new post??
xpaham la aku gune nde ni..

click dekat tajuk biochemistry cthnya,
then tekan new topic.
tapi kalau topik yang kau nak buat tu dah ada,
xyah mengada-ngada nak buat lagi.
buat serabut.
sambung je

http://wordsfromtheorient.blogspot.com/

20heme.27 march Empty Re: heme.27 march Sat May 14, 2011 8:10 am

ismipahmie

ismipahmie
Star Member
Star Member

...I'm realizing HOW to memorize the 8 Enzymes in Heme synthesis,(my own ways..), I do hope this will help anyone.. Smile :

- 2 SYNTHASE (1st and last; ALA synthase dan Heme Synthase@Ferrochelatase)
- 2 OXIDASE (Protoporphyrinogen oxidase dan Coproporphyrinogen oxidase)
- 1 DEHYDRATASE (ALA Dehydratase) [2 ALA--->PBG]
- 1 DEAMINASE ( PBG deaminase @ Uroporphyrinogen I synthase) [4 PBG--->HydroxyMethylBilane/Linear TetraPyrrole]
- 1 COSYNTHASE (Uroporphyrinogen Cosynthase @ Uroporphyrinogen III synthase) [ HydroxyMethylBilane--->URO ]
- 1 DECARBOXYLASE ( Uroporphyrinogen decarboxylase) [URO--->COPRO]

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