heme.27 march

Ok, as salam,
biarlah saya yang memulakannya,
baiklah,
hari ini ikhwah belajar tajuk heme,
synthesis and abnormalities.
akhwat pun sama juga ke?
xpasti.


ignore the hideous drawing pls.


so anybody want to share anything?
or to ask if any musykillah.
inshaAllah, ada antara batch kita yg boleh jawabkan.
this is how this forum will work.

p/s-masih menunggu subjek master biochem untuk berdaftar.

haih, memang aku buat topik nih untuk aku discuss sorg2.
kan kan kan.

Hamz!! wrote:haih, memang aku buat topik nih untuk aku discuss sorg2.
kan kan kan.

kesian nye..huk3...
xpe2 ammar..
heme snynthsis start by 2..GLYCINE AND SUCCINYL COA.
banyak step kot...

wah terharunya aku ada reply.
hekhek

dan dia menggunakan enzyme ALA synthase.kankan?
menjadi a-amino B-ketoadipcocid something,
dan berlaku di mitochondria of Bone marrow and Liver.

btw aku xamik lg lah buku biochem vol2.
cmne nih???

ya..enzyme ALA synthtse(combine wit PLP) form gamma aminolevulate...

yang pnting PBG...2 ALA combine form PBG by dehydration...enzyme nye ALA dehydratase...

oh so

Succinyl-CoA + Glycine >>>>>>>> gamma(ke delta?)-aminolevulate
(ALA-synthase)

then

2ALA>>>>>>>>>>>>>>PBG
(ALA dehydratase)

a-amino B-ketoadipcocid tu amende plak?

Hamz!! wrote:oh so

Succinyl-CoA + Glycine >>>>>>>> gamma(ke delta?)-aminolevulate
(ALA-synthase)

then

2ALA>>>>>>>>>>>>>>PBG
(ALA dehydratase)

a-amino B-ketoadipcocid tu amende plak?

a-amino B-ketoadipcocid tu keto acid 6 carbon.ia menghasilkan ALA lepas buat decarboxylation.sory kalau salah sbb ngantuk2 gak kt kelas td.

owhh,
maknanya dia dtg dpd succ-Coa dgn glycine dulu? pastu baru decarboxylation ke ALA?
i c, ic

1)pe beza erythropoietic porphyria ngn hepatic porphyria?
2) ALA may inhibit ATPase in the nervous system, cmner this inhibition cause abdominal pains + neuropsychiatric symptoms

hepatic porphyria happens when accumulating biosynthetic intermediates form in the liver and the symptoms are caused by the action of these intermediates to the nervous system.

Autonomic dysfunction causes by action on the sympa, parasym.
Pain causes by stimulation of visceral pain fibres.

So maybe jawapan ni xclear sgt.atleast ada la sikit idea.
aku malas nak baca bnyak2.
kalau rajin buka ni.page 610-611.






klikkk kalau rajin!




tak tahu la kalau dah ada dlm buku.
aku xde buku lg

hohoh...time kaseh kpd admin yg tlg buker topik....subjek master biochem pihak akhawat dh melapor diri yerrrr...yg ikhwah x tau laaa dh daftar ke blom...

sy nk bg respons kat soalan syafaf tp x tau laaa btol ker tak....
1.beza erythropoietic ngan hepatic porphyria....heme synthesis ni berlaku nyer kat liver ngan bone marrow..so,kalo erythropoietic porphyria tu bg effect kat bone marrow seterusnya menyebabkan anemia...kalo hepatic type plop,effect akn t,jadi kat liver.kat liver ader bnyk enzymes utk bnyk proses mcm gluconeogenesis,detoxification dll...so,enzymes ni akn effected la kot,...dlm text book ade state "attacks are precipitated byintake of alcohol,estrogens,and liver toxins and other forms of liver diseases."makne nyer,kalo laaa liver tu ader disease,tambah plop dgn porphyria ni,lg laa bgander-gander side effect nyer..

2.ALA may inhibit ATPase in the nervous system...kalo yg sy ingat,ATPase ni diperlukan utk sodium potassium pump kan dlm nervous system ,m.aser kiter blajo thn 1 dulu...sbb nk balancekan amount of na/k.so,kalo ATPase inhibited,akn berlaku something wrong laa kat nervous system..toxic to abdominal nerves to MAYBE sbb ALA ni bnyk accumulate kat liver tmpt heme synthesis b,laku..so,abdominal nerves laa mangser terdekat utk diserang.. kat cns plop mungkin jd neuropsychiatric symptom tu...

tp,sori laaa kalo salah.....sy x search and x rujuk maner2x pown ni...maen bantai jerr...saper yg lebey arif and faham tu,tlg bg respons yerrrr...shafaf kalo ader pndpt laen,x setuju ker,respons yerrr...

frenzyfish wrote:hohoh...time kaseh kpd admin yg tlg buker topik....subjek master biochem pihak akhawat dh melapor diri yerrrr...yg ikhwah x tau laaa dh daftar ke blom...

sy nk bg respons kat soalan syafaf tp x tau laaa btol ker tak....
1.beza erythropoietic ngan hepatic porphyria....heme synthesis ni berlaku nyer kat liver ngan bone marrow..so,kalo erythropoietic porphyria tu bg effect kat bone marrow seterusnya menyebabkan anemia...kalo hepatic type plop,effect akn t,jadi kat liver.kat liver ader bnyk enzymes utk bnyk proses mcm gluconeogenesis,detoxification dll...so,enzymes ni akn effected la kot,...dlm text book ade state "attacks are precipitated byintake of alcohol,estrogens,and liver toxins and other forms of liver diseases."makne nyer,kalo laaa liver tu ader disease,tambah plop dgn porphyria ni,lg laa bgander-gander side effect nyer..

2.ALA may inhibit ATPase in the nervous system...kalo yg sy ingat,ATPase ni diperlukan utk sodium potassium pump kan dlm nervous system ,m.aser kiter blajo thn 1 dulu...sbb nk balancekan amount of na/k.so,kalo ATPase inhibited,akn berlaku something wrong laa kat nervous system..toxic to abdominal nerves to MAYBE sbb ALA ni bnyk accumulate kat liver tmpt heme synthesis b,laku..so,abdominal nerves laa mangser terdekat utk diserang.. kat cns plop mungkin jd neuropsychiatric symptom tu...

tp,sori laaa kalo salah.....sy x search and x rujuk maner2x pown ni...maen bantai jerr...saper yg lebey arif and faham tu,tlg bg respons yerrrr...shafaf kalo ader pndpt laen,x setuju ker,respons yerrr...

klu yg kt liver tuh, amnde maksud mas? ke maksudnyer cmni... enzymes bese synthesised kt liver, kan? ke kt mner? pastu klu ad liver disease, so x ley hsilkan enzymes 4 heme synthesis, pastu x ley la bt heme snythesis, pastu pathway tersekat, accumulation of porphyrinogen,ALA,PBG then occur, pastu jd porphyria? cm2 ker??

ha ah.......sy paham mcm tu laaaa....sebijik2x samer....tp ntah lerrr kalo syok sendiri...hehehe..tp logik jer kan aper yg kiter fikir tu..

frenzyfish wrote:ha ah.......sy paham mcm tu laaaa....sebijik2x samer....tp ntah lerrr kalo syok sendiri...hehehe..tp logik jer kan aper yg kiter fikir tu..

ooo, tu klu kt liver... so klu kt bone marrow lak, sal pe lak... npe smpai leh jd anemia?? kurg RBC's production ker? amnde kaitn anemia ngn porphyria??

ooowwhhh...kaitan anemia dgn porphyria...ni yg sy paham laa....ader jer org tanyer dlm kls dulu,pastu prof jawab,..tp maser tu sy kat alam laen dah,x dgr sgt jwpn prof......kalo ader porphyria,x bley wat heme,......heme penting nk wat hemoglobin,hemoglobin penting wat rbcs.....so,biler ader porphyria,kurang heme,kurang hemoglobin,kurang rbc's.....jadi laaa anemia...

ooo...

Hamz!! wrote:oh so



Succinyl-CoA + Glycine >>>>>>>> gamma(ke delta?)-aminolevulate
(ALA-synthase)

then

2ALA>>>>>>>>>>>>>>PBG
(ALA dehydratase)

a-amino B-ketoadipcocid tu amende plak?

delta @ alpha, dua2 btl, disebabkan rotation carbon tuh..
then a-amino B-ketoadipate tuh intermiediates yg dihasilkan untuk first reaction untuk menjadi ALA , dua2 action nih guna ALA synthase

law gtu cmne aku nk wat new post??
xpaham la aku gune nde ni..

Muhammadhusnaim wrote:law gtu cmne aku nk wat new post??
xpaham la aku gune nde ni..

click dekat tajuk biochemistry cthnya,
then tekan new topic.
tapi kalau topik yang kau nak buat tu dah ada,
xyah mengada-ngada nak buat lagi.
buat serabut.
sambung je

...I'm realizing HOW to memorize the 8 Enzymes in Heme synthesis,(my own ways..), I do hope this will help anyone.. :

- 2 SYNTHASE (1st and last; ALA synthase dan Heme Synthase@Ferrochelatase)
- 2 OXIDASE (Protoporphyrinogen oxidase dan Coproporphyrinogen oxidase)
- 1 DEHYDRATASE (ALA Dehydratase) [2 ALA--->PBG]
- 1 DEAMINASE ( PBG deaminase @ Uroporphyrinogen I synthase) [4 PBG--->HydroxyMethylBilane/Linear TetraPyrrole]
- 1 COSYNTHASE (Uroporphyrinogen Cosynthase @ Uroporphyrinogen III synthase) [ HydroxyMethylBilane--->URO ]
- 1 DECARBOXYLASE ( Uroporphyrinogen decarboxylase) [URO--->COPRO]