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Discuss rhinoscleroma in details

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1Discuss rhinoscleroma in details Empty Discuss rhinoscleroma in details Sat Mar 10, 2012 4:47 am

ismipahmie

ismipahmie
Star Member
Star Member

(stump of chronic inflammation)

Definition: A chronic specific inflammation of nasal mucosa

Aetiology:
rhinosclerhoma is caused by infection of Klebsiella rhinoscleromatis.

Pathology:
Site: nose is the most common site but larynx, pharynx and upper trachea can be affected
Macro(gross): single or multiple nodular swelling filling the nasal cavity and can extend to upper lips, pharynx,larynx and upper trachea
Micro:
Nasal mucosa(covering): may show squamous metaplasia due to chronic irritation
Submucosa( core): infiltrated by chronic inflammatory cells, progressive fibroisis and endarteritis obliterans. The chronic inflammatory cells are:
1) Mikulicz cells(pathonomonic): macrophages with clear cytoplasm and central or eccentric nucleus due to hydropic degeneration
2) Plasma cells and russel bodies
3) Lymphocytes

Complications:
1) Nasal obstruction
2) Deformity
3) Epistaxis
4) Secondary bacterial infection
5) Ulceration

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