Posology(doses)

apa yg dimaksudkan dgn Standart Margin Of safety??
mcm mana nk tau sukatan yg normal?
ap yg dimksudkan dgn ED99

mintak pendedahan maksimum dr org2 berbakat..

macam kau tnya kt diri sndri je pene.ahaha

aku confuse kejap tadi, dgn L1 lah..
aku dah turun pangkat

ED99 ni kan maknanya 99% menatang terubat (efektif) bila guna dos tertentu.
LD1 pulak 1% menatang tak selamat bila guna dos tertentu jugak.
Nak tahu dos tu kena ada graf.
Baru boleh tarik-tarik.
Tapi makna SMS tu tak berapa pasti.
Ke mu tanya apa Pene?

P/s: Ammar, apsal "PostReplay"?

apa mksud ayat (a) dlm buku ?
cube explain cket mcm mne nk faham menatang tu?

Camni rasanya,
ED+LD=100%
Contoh,
ED50+LD50=100%

Sekarang,
kita nak LD1, maknanya, kena dapatkan ED99 kan?
Jadi,
berapa peratus yang kita perlu untuk dapatkan LD1 dan ED99.

Errr...
Sesiapa tolong...
Betul ke ni?

apa beza therapeutic index dgn SMS?

"SMS was defined as the zone between the surely effective dose (ED99) and the lowest lethal dose (LD1). It is expressed as a per cent of the ED99.

It was calculated by the proposed method, lays increased emphasis on the actual zone of safety between the dose almost certain to be therapeutically effective and the dose likely to cause an occasional death."

source: R.H.K. FOSTER

Kat dlm buku department:
'Percentage by which ED99 must be increased to reach LD1'

Yang saya faham stkt ni hanyalah:

-SMS merangkumi zon diantara ED99 dan LD1.(Range btween them)...sama mcm Css iaitu diantara therapeutic lvl and toxicity lvl..

-SMS merupakan % drpd ED99(high effective dose) utk mencapai LD1(lowest lethal dose).

-cth: SMS=23%
*ED99 perlu dinaikkan sehingga 23% utk mencapai
LD1.

p/s: kalu ade slh, minta perbetulkan..tk

tak faham

naqiyan wrote:tak faham

Payapaya likes this.

pahmie :

bley trangkan ikut formula yg dia bg tuh x?


naqiyan :

haah kan, cm menarik je soklan tuh..

nk tggu spe lg nk xplain pasal SMS tuh ..
tp nk tnyer gak..sesapa tolong jwab..

pe beza chronic effect(type c) ngn delayed effects(type D) of drugs? both effect when prolonged use of drugs an..so , guana nk beza ?

ni yg saya fhm pasal SMS tu..

e.g: doc bg drug 50 mg kpd 100 binatang = 99 yg ok (ED)
pstu bg plak yg high dose ckit, 80 mg = 1 mati (LD)

so, SMS= ((80/50)-1) x 100 (gna formula die bg)
= (1.6-1) x 100
= 60 %

so, 60% tu la SMS.

cam tu la apa yg diri ni paham..kalau salah, tolong betulkn

wnwh wrote:ni yg saya fhm pasal SMS tu..

e.g: doc bg drug 50 mg kpd 100 binatang = 99 yg ok (ED)
pstu bg plak yg high dose ckit, 80 mg = 1 mati (LD)

so, SMS= ((80/50)-1) x 100 (gna formula die bg)
= (1.6-1) x 100
= 60 %

so, 60% tu la SMS.

cam tu la apa yg diri ni paham..kalau salah, tolong betulkn

ohh,jap..

kalau bg 50mg,99 binatang ok,1 lagi jadi pe? mati ke?
kalau bg 80mg,1mati,99 jadi pe? hidup?

haha,maaf lah.confused.

and,ape kepentingan tau result 60% tu?

[/quote]

ohh,jap..

kalau bg 50mg,99 binatang ok,1 lagi jadi pe? mati ke?
kalau bg 80mg,1mati,99 jadi pe? hidup?

haha,maaf lah.confused.

and,ape kepentingan tau result 60% tu?[/quote]


dear naqian...
total no. bintang yg d uji kaji adlah 100
bila bg 50mg ubat 99 binatang drpd 100 tu hidup..
n bila bg 80mg ubat 1 drpd 100 tu mati..

tu apa yg sy paham brdasarkan explaination itu..

ok,da nmpak dah xplaination formula tu..
thnks la..

* smbil berharap mkin ramai menyertai forum termasuk AJK dan juga SM2 yg terlibat..

*SMS mkin besar mkin selamat ea?

tyme lecture ada perasan lecture ckp
it must be > 1 to be the drug usable..

sape2 faham x mksud tu? ni pasal sms..

adkah (LD/ED) must be > than 1??

afnan fakhrurazi wrote:ok,da nmpak dah xplaination formula tu..
thnks la..

*SMS mkin besar mkin selamat ea?

yup, SMS makin besar makin slamat la drug tu, sbb % yg bnyk tu mksudnya doc kena naikkan bnyk dose baru ade yg mati..kalu SMS tu ckit, doc naikkan dos tu sikit pon, da ade yg mati