afnan fakhrurazi wrote: naqiyan wrote:tak faham. tak faham. hmmm....
apa maksud K leaves the cell in exchange for H from ECF?
ini part BARTTER,(ye masih di bartter lagi..huhu)
*kalau xde nk jawab xpe je,paham je semua tgh study... (-__-)
ayat tu dia ckp sebab berlakunya alkalosis ( sebab dia letak bracket ) kan2?
rasenya gini j kot..kan loss of K = hypokalcemia kan?
so feedback dia nk increase balik K conc. tuh..
jadi cranya dgn take K from the cell ( K kan more intracellular )
jadi dia gunakan H/K atpase tranporter ( ada dia ckp dlm K handling tuh )
so, dia tukar la jadik H into the cell ( decreased dlm ECF )
tp K into the ECF ( decreased in the cell )
** sebenrnya ni hnyalah andaian semata2 sebab xd info yg lengkap n terperinci
** rasanya main point dia nk ckp metabolic alkalosis j kot kat citu
** dia mungkin confuse cikit dgn komen atas2 pasal aldosterone kan ? tp rasanya dua2 berlaku serentak
oooo...aku faham daaa sekarang...terima kasih byk2.. (^_^)
logic je teori ni,sbb nya,bila rujuk K handling kat m/s 61,
dia kata reabsorption of K kat DCT and collecting tubule tu guna H/K ATPase system,yang mana
HANYA AKAN BERLAKU WHEN LOW K(K DEPLETION) i.e. seperti case bartter syndrome la kn..
so,thats y lah dia kata K leave the cells in exchange with the H fom ECF.
kalau kita confused dgn action aldosterone yg cause hypokalemia tu,sebenanrnya action aldosterone tu berlaku kat
P cell of collecting duct,ikut Na/K exchange.
and at the same time sebenarnya berlaku jugak H/K exchange kat
I cell.bezanya,Na/K exchange tu aim dia nak increasekan semula Na dlm badan,dan H/K exchange tu nak increasekan K dalam badan.
hmmm...maaf kalau aku salah faham,mintak betulkan semula,tp setakat ni aku faham dah maksud kau bg ni afnan,tengs2!